Non-rigid MR-CT Image Registration

Non-rigid MR-CT Image Registration Tutorial

Overview

This tutorial demonstrates how to perform a pre-operated contrast enhanced MR image to intra-procedure CT image non-rigid registration. The case study is CT-guided liver tumor cryoablation.

NON-RIGID MR-CT IMAGE REGISTRATION: As shown in this figure, non-rigid registration can enhance visualization of tumor margin and location.

Clinical significants

• Non-rigid registrations desirable to compensate for liver deformation caused by patient positioning, respiratory motion, and interventional manipulation.
• A multi-modality non-rigid registration method can enhance visualization of tumor margins and location during the planning, targeting, and monitoring phases of CT imaging-guided cryoablation procedure.

IMAGE PROCESSING IN CRYOABLATION OF LIVER CASE: In CT-guided cryoablation, there are a non-rigid registration (red line), an affine registration (green line) and a resampling (yellow line) as shown in this figure. These three tasks will be performed in this tutorial.

Tutorial Topics / Targets

• Slicer Modules Used:
  • N41ITKBiasField Correction
  • Editor
  • BRAINSFitIGT Registration
• Image Processing Tasks Performed:
  • Intensity non-uniformly correction
  • Mask generation / segmentation
  • Inter-modality non-rigid image registration
• Image Data Used:
  • Pre-operative abdominal MR with surface coil, showing liver
  • Planning and Intra-operative CT with cryo-probe

REGISTRATION STRATEGY / ROADMAP:

Overview

• This tutorial will go through the following steps (in order):
• Preprocessing
  • MRI mask generation
  • CT mask generation
  • MRI Bias Field Intensity Correction
• Registration
  • MRI-CT non-rigid registration
  • CT-CT affine registration
  • Resampling & Fusion

Tutorials

Non-rigid MR-CT Image Registration Tutorial ‏ [ppt]‏ [pdf]

Tutorial materials

Material data:

• Non-rigid_MR_CT_Image_RegistrationTutorialData_TutorialContestSummer2011.tar.gz

People

Atsushi Yamada, Ph.D. (Research Associate, Brigham and Women's Hospital and Harvard Medical School)
Dominik S. Meier, Ph.D. (Assistant Professor, Brigham and Women's Hospital and Harvard Medical School)
Nobuhiko Hata, Ph.D. (Associate Professor, Brigham and Women's Hospital and Harvard Medical School)