Difference between revisions of "PA/A Tool"

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Image:PW-2015SLC.png|[[2015_Winter_Project_Week#Projects|Projects List]]
 
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Image:Screen Shot 2015-01-05 at 15.09.46.png | Pulmonary Artery over Aorta ratio
 
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<h3>Objective</h3>
 
<h3>Objective</h3>
*Calculate in a fast way the ratio of the major and minor axis of the aorta in a chest CT slice where the pulmonary artery is clearly visible. This ratio is a biomarker used to detect aorta calcification.
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*Calculate the ratio between the diameters of aorta and pulmonary artery, as a biomarker of acute exacerbations of COPD.
For more information about the medical need:  
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*Calculate in a fast way the ratio of the major and minor axis of the aorta in a chest CT slice where the pulmonary artery is clearly visible. This ratio is a biomarker used in pulmonary vascular disease and has been associated with outcomes like exacerbations.
*J. M. Wells, G. R. Washko, M. K. Han, N. Abbas, H. Nath, A. J. Mamary, E. Regan, W. C. Bailey, F. J. Martinez, E. Westfall, T. H. Beaty, D. Curran-Everett, J. L. Curtis, J. E. Hokanson, D. A. Lynch, B. J. Make, J. D. Crapo, E. K. Silverman, R. P. Bowler, M. T. Dransfield, the COPDGene and ECLIPSE Study Investigators, “Pulmonary Arterial Enlargement and Acute Exacerbations of COPD.,” N. Engl. J. Med., vol. 367, no. 10, pp. 913–921, Sep. 2012.
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For more information about the medical need: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690810/?tool=pmcentrez Pulmonary Arterial Enlargement and Acute Exacerbations of COPD]
 
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<h3>Approach, Plan</h3>
 
<h3>Approach, Plan</h3>
 
*Phase 1:
 
*Phase 1:
** Give the expert a simple mecanism to measure the aorta's major and minor axis in the best slide possible to detect calcification (this could include an automatic tool to detect which is the best slide)
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** Give the expert a simple mecanism to measure the aorta and pulmonary artery is in the best slide possible (this could include an automatic tool to detect which is the best slide)
** Once the user has measured manually the two axis, calculate the ratio automatically.
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** Calculate the ratio automatically.
  
 
* Phase 2:
 
* Phase 2:
** Completely automatic segmentation of the best slide and the two aorta axis for an expert validation.
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** Completely automatic measurement of aorta and pumonary artery for an expert validation.
 
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<h3>Progress</h3>
 
<h3>Progress</h3>
* First steps in aorta/pulmonary artery segmentation
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* Markups are automatically set according to the structure that the user has selected
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[[File:Aorta.png|300px]]
 
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Latest revision as of 01:49, 9 January 2015

Home < PA < A Tool

Key Investigators

Jorge Onieva, Rola Harmouche, German Gonzalez

Project Description

Objective

  • Calculate the ratio between the diameters of aorta and pulmonary artery, as a biomarker of acute exacerbations of COPD.
  • Calculate in a fast way the ratio of the major and minor axis of the aorta in a chest CT slice where the pulmonary artery is clearly visible. This ratio is a biomarker used in pulmonary vascular disease and has been associated with outcomes like exacerbations.

For more information about the medical need: Pulmonary Arterial Enlargement and Acute Exacerbations of COPD

Approach, Plan

  • Phase 1:
    • Give the expert a simple mecanism to measure the aorta and pulmonary artery is in the best slide possible (this could include an automatic tool to detect which is the best slide)
    • Calculate the ratio automatically.
  • Phase 2:
    • Completely automatic measurement of aorta and pumonary artery for an expert validation.

Progress

  • Markups are automatically set according to the structure that the user has selected

Aorta.png