Mbirn: MAD: Description of Development Plan

UPDATED 2005.07.26 (C. Fennema-Notestine)

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Study 1 (CFN, BD, RG)

• *** estimate true site effects
  • • replicate findings already reported in the literature for single site studies such as
      • normal aging related volume loss
      • sex effects and interactions
      • education effects

Study 2 (CFN, BD, RG)

• *** replicate published findings from our groups and others showing greater volume loss in subjects who convert to AD or who are diagnosed with AD.
  • • examine the relation between volume loss and dementia severity (using MMSE as the critical variable) within impaired groups.
    • examine the relation between volume loss and memory as measured by neuropsychological assessments.

Study 3 (CR, CFN, AD, BD, RG)

For more information see:

• MAD: Project Background
• MAD: Updates

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