Projects:RegistrationDocumentation:ParameterTesting

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ISMRM abstract 2010

• Title: Protocol-Tailored Automated MR Image Registration
• Authors: Dominik Meier, Casey Goodlett, Ron Kikinis
• Significance: Fast and accurate algorithms for automated co-registration of different MR datasets are commonly available. But systematic knowledge or guidelines for choosing registration strategies and parameters for these algorithms are lacking. As image contrast and initial misalignment vary, so do the appropriate choices of cost function, initialization and optimization strategy. To find a successful registration, the clinical research end user is currently forced to resort to trial and error, which is ineffcient and yields suboptimal results. Registration problems also contain an inherent tradeoff between accuracy and robustness, and the landscape of this tradeoff also is largely unknown.
• Objective: Determine guidelines for affine registration of intra-subject multi-contrast MRI data within the 3DSlicer software. This work will present approaches and solutions for successful registration for a large set of combinations of MRI pairings. This is part of a concerted effort to build a Registration Case Library available to the medical imaging research community.

• Method:
  • xx brain MRI pairs from 4 different subjects with optimal registrations were selected. The pairs represent all 6 contrast combinations of T1,T2,FLAIR and PD. Each pair was then disturbed by a known validation transform and subsequently registered again under different parameter settings. Registration success was evaluated as the extent to which the initial position could be recovered, reported as distributions of RMS of all points within the brain. Included in the variations were 1) degree of initial misalignment (6 levels), 2) cost function (MI, NCorr, MSq), 3) %-sampling ratio (1%,2%,5%), yielding 54 individual registration results per case, xx registrations total.
  • 1- choose 3-4 subjects/exams with 3-4 different contrast pairings: T1, T2, PD, FLAIR: ~12-16 images. We choose sets for which we have a good registration solution
  • 2- disturb each pair by a known transform of varying rotational & translational misalignment
  • 3- run registration for a set of parameter settings and save the result Xform, e.g. metric: NormCorr vs. MI , 2% vs 5% sampling, 50 vs. 100 iteration max
  • 4- evaluate registration error as point distance and RMS.
  • 5- run sensitivity analysis and report the best performing parameter set for each MR-MR combination
• This self-validation scheme avoids recruiting an expert reader to determine ~ 3-5 anatomical landmarks on each unregistered image pair (time constraint). Also we can cover a wider range of misalignment and sensitivity by controlling the input Xform. It also facilitates batch processing.
• Results:
  • Performance is relative insensitive to parameter permutations if misalignment is below 5 degrees, i.e. for small adjustments many settings yield success
  • Above 5 degrees parameter influence becomes non-contiguous: as shown by results small variation in input parameter can produce drastically different results.
  • Registration failure sets in, disregarding of (singular) parameter settings, above 15 degrees rotational misalignment.
  • higher sampling rates do not necessarily promise better results, but 2% seems a lower bound unless speed is a critical issue
  • PipelineAffine outperforms Affine in almost all instances.
  • UPDATE: Metric comparison: mutual Info, norm corr, msqrd
  • UPDATE: masking comparison: effect of masking on robustness
  • UPDATE: initialization (none, image center, center of mass, 2nd moment)
  • UPDATE: search step sizes (rotational, translational) : have an effect but could be considered heuristics that ought to be determined by the algorithm
  • UPDATE: Bias field comparison: at what level of inhomogeneity does performance degrade. Which cost function is more robust against inhomogeneity?