Difference between revisions of "2013 Project Week:PkModeling for prostate DCE MRI"
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* The main source of the inconsistency was due to different models used by the two tools being compared: 2-parameter (Ktrans+ve) vs 3-parameter (Ktrans+ve+fpv). After fixing this, the results were very similar (difference <1% vs 1000%). | * The main source of the inconsistency was due to different models used by the two tools being compared: 2-parameter (Ktrans+ve) vs 3-parameter (Ktrans+ve+fpv). After fixing this, the results were very similar (difference <1% vs 1000%). | ||
* Bolus arrival time was not estimated in the Slicer PkModeling tool. | * Bolus arrival time was not estimated in the Slicer PkModeling tool. | ||
| − | * | + | * Work in progress: |
| + | ** Andrey: update the code to propagate model selection through various layers/filters of the module | ||
| + | ** Jim: look into the issue of synchronizing bolus arrival time for the plasma/tissue curves | ||
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Latest revision as of 00:16, 11 January 2013
Home < 2013 Project Week:PkModeling for prostate DCE MRI
Key Investigators
- BWH: Andrey Fedorov
- GE: Jim Miller
Project Description
Objective
- debug and test the pharmacokinetic modeling extension on prostate DCE MRI data
Approach, Plan
- previously validated non-open-source implementation of the PK modeling will be used as reference for comparison with the results produced by PkModeling extension
- prostate DCE MRI data will be used for testing using identically defined AIF
- success will be achieved if the results produced by PkModeling and the reference software agree
Progress
- The main source of the inconsistency was due to different models used by the two tools being compared: 2-parameter (Ktrans+ve) vs 3-parameter (Ktrans+ve+fpv). After fixing this, the results were very similar (difference <1% vs 1000%).
- Bolus arrival time was not estimated in the Slicer PkModeling tool.
- Work in progress:
- Andrey: update the code to propagate model selection through various layers/filters of the module
- Jim: look into the issue of synchronizing bolus arrival time for the plasma/tissue curves
