Difference between revisions of "NA"

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  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
 
  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
  
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'''Objective:''' To quantify changes in diffusion properties along the cingulum bundle for schizophrenics and normal controls.
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'''Objective:''' Previous studies have observed morphological abnormalities of the corpus callosum in schizophrenia (link to paper below), while other studies have shown abnormal brain activation during memory tasks. The goal of this project is to examine the integrity of fibers in the corpus callosum in patients with schizophrenia and determine whether this is associated with brain activation during memory tasks.
  
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'''Progress:''' We improved the diffusion MRI module in slicer to allow for a better fiber selection (based on multiple regions of interest) as well as fiber clustering. We set up a processing pipeline to allow for statistical computations of fiber diffusion properties across the fibers of a fiber bundle and along the bundle itself. Further, we are in the process of developing a continuous representation of fiber bundles (see Figure) to allow for a more geometric computation of bundle diffusion quantities.
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'''Progress:''' Fiber tractography method developed and we have begun to apply it to data collected thus far. An example is pictured below. A link to sample DTI data is also below. [[Image:NAMIC_callosum_tracts_prelim.jpg|[[Image:NAMIC_callosum_tracts_prelim.jpg|Image:NAMIC_callosum_tracts_prelim.jpg]]]]
  
 
'''Key Investigators:'''
 
'''Key Investigators:'''
  
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* Harvard PNL: Marc Niethammer, Sylvain Bouix, Marek Kubicki, Mark Dreusicke, Martha Shenton
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* Dartmouth: John West, Andrew Saykin, Laura Flashman, Paul Wang
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* MIT: CF Westin, Lauren O'Donnell, Raul San Jose
 
  
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'''Links:'''
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'''Links'''
  
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* [[DBP:Harvard:Collaboration:MITDTI|DBP:Harvard:Collaboration:MITDTI]]
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* Paper, Neurobiology of Aging, in press: [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T09-4HGM701-3&_user=489293&_handle=V-WA-A-W-AEU-MsSAYZW-UUW-U-AAVEAEAWVU-AAVZDDWUVU-YVUCEAAYD-AEU-U&_fmt=summary&_coverDate=11%2F04%2F2005&_rdoc=95&_orig=browse&_srch=%23toc%234857%239999%23999999999%2399999!&_cdi=4857&view=c&_acct=C000022698&_version=1&_urlVersion=0&_userid=489293&md5=721faeff8b07e7d57550a5c5f921a498 Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints]
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* http://pnl.bwh.harvard.edu/index.html
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* [[DBP:Marek_Kubicki_visit_Dartmouth_December_20_2005|December 20, 2005: Marek Kubicki visit to Dartmouth]]
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* [[DBP:Andy_Saykin_visit_BWH_December_14_2005|December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital]]
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'''Representative Image and Descriptive Caption:'''
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* Sample Data: https://portal.nbirn.net/BIRN/cgi-bin/DataGrid/browse.cgi?browseloc=/home/Projects/NAMIC__0003/Files/Dartmouth/HealthyControls6
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<div class="thumb tleft"><div style="width: 402px">[[Image:Cingulum_reseeded_withtrajectories.png|[[Image:400px-Cingulum_reseeded_withtrajectories.png|Cingulum bundle with arclength parameterization.]]]]<div class="thumbcaption"><div class="magnify" style="float: right">[[Image:Cingulum_reseeded_withtrajectories.png|[[Image:magnify-clip.png|Enlarge]]]]</div>Cingulum bundle with arclength parameterization.</div></div></div>
 

Revision as of 13:28, 18 December 2006

Home < NA
Back to NA-MIC_Collaborations

Objective: Previous studies have observed morphological abnormalities of the corpus callosum in schizophrenia (link to paper below), while other studies have shown abnormal brain activation during memory tasks. The goal of this project is to examine the integrity of fibers in the corpus callosum in patients with schizophrenia and determine whether this is associated with brain activation during memory tasks.

Progress: Fiber tractography method developed and we have begun to apply it to data collected thus far. An example is pictured below. A link to sample DTI data is also below.

Key Investigators:

  • Dartmouth: John West, Andrew Saykin, Laura Flashman, Paul Wang

Links

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