Difference between revisions of "NA"

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  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
 
  Back to [[NA-MIC_Collaborations|NA-MIC_Collaborations]]
  
'''Objective:'''
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'''Objective:''' To improve shape analysis of the caudate and to parcellate the corpus callosum based on function.
 
 
To make new filters more accessible to the medical imaging community. These filters include geometric nonlinear smoothing filters for enhancement and a modified Bayesian classifier for segmentation.
 
  
 
'''Progress:'''
 
'''Progress:'''
  
* Various anisotropic enhancement and Bayesian filters have been incorporated into ITK.
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* UNC applied shape analysis pipeline to a dataset of manually segmented caudates of males with and without schizoptypal personality disorders. Differences were found mainly on the right caudates. No differences were found for regional parcellations of the corpus callosum.
** [[http://www.itk.org/Insight/Doxygen/html/classitk_1_1BayesianClassifierImageFilter.html Bayesian Classifier Image Filter]]
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* The open source shape analysis pipeline was transfered and installed at Harvard PNL.
** [[http://www.itk.org/Insight/Doxygen/html/classitk_1_1BayesianClassifierInitializationImageFilter.html Bayesian Classifier Initialization Image Filter]]
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* Harvard applied the UNC shape analysis software to a new dataset of manually segmented caudates of females with and without schizotypal personality disorder. The results confirmed previous findings in the male dataset. Statistically significant shape differences for the right caudate were found (see Fig 1).
* A paper was published in the (Open Access) Insight Journal
 
** [[https://caddlab.rad.unc.edu/MIDAS/handle/1926/44 Knowledge-Based Segmentation of Brain MRI Scans Using the Insight Toolkit]]
 
  
 
'''Key Investigators:'''
 
'''Key Investigators:'''
  
* Georgia Tech: John Melonakos, Allen Tannenbaum
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* Harvard PNL: Sylvain Bouix, Marek Kubicki, James Levitt, Marc Niethammer, Martha Shenton
* Kitware: Karthik Krishnan, Luis Ibanez
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* UNC: Martin Styner, Isabelle Corouge, Guido Gerig
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* Georgia Tech: Delphine Nain, Allen Tannenbaum
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{|
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|+ '''Fig 1. Right female caudate results'''
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|-
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| valign="top" |
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<div class="thumb tright"><div style="width: 252px">[[Image:Rawpval_rc_back_min.png|[[Image:250px-Rawpval_rc_back_min.png|Medial]]]]<div class="thumbcaption"><div class="magnify" style="float: right">[[Image:Rawpval_rc_back_min.png|[[Image:magnify-clip.png|Enlarge]]]]</div>Medial</div></div></div>
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| valign="top" |
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<div class="thumb tright"><div style="width: 277px">[[Image:Rawpval_rc_front_min.png|[[Image:275px-Rawpval_rc_front_min.png|Lateral]]]]<div class="thumbcaption"><div class="magnify" style="float: right">[[Image:Rawpval_rc_front_min.png|[[Image:magnify-clip.png|Enlarge]]]]</div>Lateral</div></div></div>
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| valign="top" |
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<div class="thumb tright"><div style="width: 52px">[[Image:Rawpval_rc_colorbar_min.png|[[Image:50px-Rawpval_rc_colorbar_min.png|p value]]]]<div class="thumbcaption"><div class="magnify" style="float: right">[[Image:Rawpval_rc_colorbar_min.png|[[Image:magnify-clip.png|Enlarge]]]]</div>p value</div></div></div>
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|}
  
 
'''Links:'''
 
'''Links:'''
  
* [[Algorithm:GATech#ITK_Bayesian_Classifier_Image_Filter|Georgia Tech Summary Page]]
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* [[Progress_Report:Shape_Analysis|Shape Analysis Progress Report]]
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* [[DBP:Harvard:Collaboration:UNC|DBP:Harvard:Collaboration:UNC]]
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* [[DataRepository#Brockton_VA.2FHarvard_Structural_and_DTI_Images|Male caudate data]]

Revision as of 13:29, 18 December 2006

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Back to NA-MIC_Collaborations

Objective: To improve shape analysis of the caudate and to parcellate the corpus callosum based on function.

Progress:

  • UNC applied shape analysis pipeline to a dataset of manually segmented caudates of males with and without schizoptypal personality disorders. Differences were found mainly on the right caudates. No differences were found for regional parcellations of the corpus callosum.
  • The open source shape analysis pipeline was transfered and installed at Harvard PNL.
  • Harvard applied the UNC shape analysis software to a new dataset of manually segmented caudates of females with and without schizotypal personality disorder. The results confirmed previous findings in the male dataset. Statistically significant shape differences for the right caudate were found (see Fig 1).

Key Investigators:

  • Harvard PNL: Sylvain Bouix, Marek Kubicki, James Levitt, Marc Niethammer, Martha Shenton
  • UNC: Martin Styner, Isabelle Corouge, Guido Gerig
  • Georgia Tech: Delphine Nain, Allen Tannenbaum
Fig 1. Right female caudate results
Medial
Enlarge
Medial
Lateral
Enlarge
Lateral
p value
Enlarge
p value

Links: