Projects:FractionalAnisotrophyInTheUncinateFasciculus

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Objective: To measure the FA in the uncinate fasciculus in patients with schizophrenia. This project is based on the methods published by Kubicki et al. and extends that work by including a bipolar disorder control group, and determining whether there is an association between FA and cognitive functioning and symptoms in the patient groups.

Progress: DTI data has been collected in 12 patients with schizophrenia, 15 healthy controls and 8 patients with bipolar disorder. Initial practice at identifying coronal slice of uncinate fasciculus completed (see figure below for example). Visit to Dartmouth by Dr. Kubicki to discuss methodology. A link to sample DTI data is available below.

Progress from AHM 2007: Training on fiber tractography in Slicer with Sylvain Bouix that we can apply to this project as well as investigation of other fibre tracts such as the cingulate bundle.

Key Investigators:

• Dartmouth: Heather Pixley, Robert Roth, Laura Flashman, Andrew Saykin, John West
• Harvard: Marek Kubicki

Links

• December 20, 2005: Marek Kubicki visit to Dartmouth
• December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital
• Sample Data: https://portal.nbirn.net/BIRN/cgi-bin/DataGrid/browse.cgi?browseloc=/home/Projects/NAMIC__0003/Files/Dartmouth/HealthyControls6