Projects:CorpusCallosumFiberTractography

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Objective: Previous studies have observed morphological abnormalities of the corpus callosum in schizophrenia (link to paper below), while other studies have shown abnormal brain activation during memory tasks. The goal of this project is to examine the integrity of fibers in the corpus callosum in patients with schizophrenia and determine whether this is associated with brain activation during memory tasks.

Progress: Fiber tractography method developed and we have begun to apply it to data collected thus far. An example is pictured below. A link to sample DTI data is also below.

Key Investigators:

• Dartmouth: John West, Andrew Saykin, Laura Flashman, Paul Wang

Links

• Paper, Neurobiology of Aging, in press: Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints
• December 20, 2005: Marek Kubicki visit to Dartmouth
• December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital
• Sample Data: https://portal.nbirn.net/BIRN/cgi-bin/DataGrid/browse.cgi?browseloc=/home/Projects/NAMIC__0003/Files/Dartmouth/HealthyControls6