MeningiomaMRIRegistrationStudy

Objective

Accurate registration of same patient/same modality MRI data for longitudinal analysis of tumor progression.

Specific Aims

1. Compare the accuracy of registration using existing Slicer and non-Slicer tools
2. Identify parameter settings that produce satisfactory results
3. Outline the limitations of the available registration tools in the context of the specific clinical research application

Data

• Input images: isotropic post-contrast T1 MRI acquired at different locations of BWH during 2006-2008, used under medical records study IRB. Time period between acquisition of scans for each patient is about 1 year.
• Ground truth transformation: not available
• Expert landmarks for registration evaluation: not available
• Checkerboard appearance of unregistered images for the representative data of interest

• • Case01

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• • Case03

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• • Case04

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• • Case10

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Measures of success

• qualitative assessment: visually pleasing results
• quantitative assessment: something better than "visually pleasing" (TBD)
• minimum execution time to meet the application requirements: interactive quantification of tumor growth

Methods

Registration

FSL FLIRT

• FSL FLIRT
• Technical details
• parameters:

flirt -in ${TIME_POINT_2} -ref ${TIME_POINT_1} -omat ${FLIRT_TRANSFORM} -out ${RESAMPLED_IMAGE} -dof 6 -v

• execution time: ~4 min