2012 Winter Project Week: Continuous 4D shapes

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  Projects List

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  Snapshot of sub-cortical shape evolution. Color denotes magnitude of velocity.

Key Investigators

James Fishbaugh, Hans Johnson, Guido Gerig

Objective

During the 2011 summer project week, we applied our shape regression framework to sub-cortical shapes from a single HD subject. For this project, we plan to begin processing multiple subjects. We would like to compare the trajectories of various measurements of interest, such as volume, across subjects at different stages of disease progression.

Approach, Plan

• Estimate continuous trajectories for sub-cortical structures for multiple subjects
• Investigate volume changes between subjects at different stages of disease progression
• Explore shape evolution for other potentially significant measurements

Progress

Fig 1. Volume of sub-cortical segmentations for 6 HD subjects.

References

• Fishbaugh, J., Durrleman, S., Gerig, G. A Framework for Longitudinal Data Analysis via Shape Regression . SPIE Medical Imaging 2012: Image Processing. Vol. 8314. (To appear)

• Fishbaugh, J., Durrleman, S., Gerig, G. Estimation of Smooth Growth Trajectories with Controlled Acceleration from Time Series Shape Data. Proc. of Medical Image Computing and Computer Assisted Intervention (MICCAI '11). September 2011.