2014 Project Week:PkModeling user tool
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Key Investigators
- BWH: Andrey Fedorov, Alireza Mehrtash, Ron Kikinis
- MGH: Jayashree Kalpathy-Cramer
- GE: Jim Miller
- Isomics: Steve Pieper
Project Description
Objective
- Our goal is to develop an interactive module in 3D Slicer to help non-technical user do PK modeling. This module will wrap PkModeling extension CLI, possibly other pre-/post-processing tools, guide the user through the various choices that can be made, generate the maps and collect the summary statistics that will eventually be saved in a standard form.
Approach, Plan
- discuss the desired capabilities of the module and its design
- review the various components available in Slicer, or in the process of being integrated into Slicer that can be used by the module
- test PkModeling functionality on the datasets from BWH and MGH
Progress
- Design ideas: 3 modules of increasing complexity
- one-click analysis: minimum interaction: fixed T1, population (model) AIF, produce maps and summary statistics
- minimum user guidance: add manual AIF ROI definition for patient-specific AIF, allow direct ROI definition on the multivolume node
- full analysis: choice of manual/auto/model AIF, T1 map based on FA/TR/IR
- components to be added:
- T1 modeling: FreeSurfer mri_ms_fitparams?
- automatic AIF detection (MGH tool)
- R2* correction from dual-echo sequence (MGH)
- Features to be added to PkModeling
- accept multivolume in concentration units (defined based on an attribute in the header, in the future need to consider adding units information to the Slicer volumes, on import?)
- add population AIF
- tested PkModeling on MGH brain DCE
