DBP:Harvard:Collaboration:MITDTI

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Current Projects

Diffusion measures along fiber tracts of the cingulum bundle
- We are trying to obtain diffusion measures (FA, trace, etc.) along fiber tracts of the cingulum bundle, comparing schizophrenic patients with control subjects.
- Participants:
  - MIT: CF Westin, Lauren O'Donnell, Raul San Jose
  - PNL: Marc Neithammer, Sylvain Bouix, Marek Kubicki, Mark Dreusicke
Clustering of anatomically distinct fiber tracts
- Lauren O'Donnell (LMI) has developed a method to cluster fiber tracts based on their location and the regions they connect
- Participants:
  - MIT: Lauren O'Donnell, CF Westin
  - PNL: Marek Kubicki, Mark Dreusicke, Martha Shenton
FA/trace measurements of the corpus callosum and anterior commissure
- Using ROI labelmaps drawn on sagittally acquired DTI data (higher resolution in sagittal plane), we are calculating diffusion measures in the corpus callosum and anterior commissure of schizophrenic patients.
- This project has involved the coregistration of sagittal and coronal tensor data.
- Fiber tracking (and clustering) is currently being applied to these cases
- Participants:
  - MIT: Lauren O'Donnell, CF Westin, Scott Hoge
  - PNL: Marek Kubicki, Mark Dreusicke

Software Testing: Scalar measure outputs from the DTMRI module of Slicer (FA and trace) are being compared with standard protocol measurements.
Fiber tracking using multiple ROIs: We are testing the use of multiple ROIs to identify fiber tracts of interest.
Fiber clustering: A unique method has been developed to cluster fiber tracts based on their anatomical connectivity.
High resolution DTI acquisition: We are experimenting with the fiber tracking of higher resolution DTI scans.
Coregistration of sagittal/coronal DTI: To use ROI labelmaps drawn on sagittally acquired data, we have developed a method to coregister the tensors of sagittal and coronal scans, so that labelmaps can be applied to full-brain coronal DTI acquisitions.
DICOM files: We have ensured that DICOM DTI images are able to read in the Slicer.
Masking FA/trace maps: Because of file type incompatability, scalar volumes from the DTMRI module could not be masked with ROI labelmaps. The problem has since been solved.

Lauren O'Donnell, Carl-Fredrik Westin. White Matter Tract Clustering and Correspondence in Populations. MICCAI 2005
Lauren O'Donnell, Marek Kubicki, Martha E. Shenton, W. Eric L. Grimson, Carl-Fredrik Westin. A Method for Clustering White Matter Fiber Tracts. AJNR (In Press)