CTSC:multicenter101410

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Agenda

1. establishment of the first virtual trial

Multicenter Clinical Trail Working group Meeting Minutes October 14, 2010

In attendance:

• Valerie Humblet
• Bob Lenkinski
• Clare Tempany
• Charles Guttmann
• Simon Warfield

MRI neuroimaging virtual trial

• It will be done with 3T MRI scanners, without contrast, with a multi-element head coil. Three sequences will be run: T2 weighted, FLAIR and MP RAGE. We will Implement common protocol with human phantoms.

Bodypart: neuroimaging, there is already a common neuro protocol for pediatric MS.

take the dataset and look for reproducibility for 3 outcome measures; total brain volume, CFS and white/gray matter. understand where protocols are equivalent and different. Need to understand intra- and inter- variability Test difference obtained with different version of same software

Extension to other disease and modalities

• We offer recommendation on the best phantoms for a specific disease. We also offer advices on calibration of theses phantoms.