2011 Winter Project Week:Intra-ProceduralProstateMotion
Key Investigators
- BWH: Andrey Fedorov
- Queens University: Andras Lasso
Objective
Multi-parametric diagnostic MRI was shown to be important in localization of prostate cancer. MR-guided prostate cancer biopsy (using transperineal access at BWH, transrectal access at Queens) performed in the closed bore MR scanner relies on image registration between the intra-procedural configuration of the prostate gland and the pre-procedural diagnostic MRI to locate the suspected cancer regions and guide the biopsy sample collection. Intra-operative image acquisition includes a volumetric scan of the whole prostate gland in the beginning of the procedure, followed by single-slice acquisitions throughout the procedure with the purpose of confirming biopsy needle location. In the current image processing workflow, the diagnostic MRI is registered with the initial intra-procedural MRI.
One of the challenges we are facing is the motion and deformation of the prostate gland during the course of the procedure, which is typically ~1 hour long. Significant patient motion may invalidate the result of the initial pre- to intra-procedural MRI registration.
Our objective is to develop robust image acquisition and registration protocols to detect and compensate for the intra-procedural prostate motion/deformation, preferably using single-slice acquisitions throughout the procedure.
Approach, Plan
- evaluate and compare the solutions developed at BWH and Queens for volume-to-slice registration on the common data
- seek input from NA-MIC registration experts on the design of the registration approach
- discuss the high-level approach and plans for integrating volume-to-slice registration functionality into ProstateNav Slicer module
- discuss with Slicer engineering core plans and challenges in improving support for deformable transformations in 3D Slcer
