2011 Summer Project Week long shape regression

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Longitudinal Shape Regression - Huntington's Disease

Key Investigators

  • Utah: James Fishbaugh, Marcel Prastawa, Guido Gerig
  • Iowa: Hans Johnson


Objective

To begin processing longitudinal Huntington's disease data and to apply our shape regression framework to available data. We are interested in the evolution of sub-cortical structures in the brain.

We would like to estimate continuous growth scenarios for several shapes of interest, which can eventually be combined with a framework for 4D registration or 4D atlas construction, to statistically analyze the growth variability within a population.

Approach, Plan

  • Segment sub-cortical structures
  • Estimate growth trajectories

Progress


Evolution of sub-cortical structures.

References

Fishbaugh, J., Durrleman, S., Gerig, G. "Estimation of Smooth Growth Trajectories With Controlled Acceleration From Time Series Shape Data". MICCAI 2011. To appear.