2012 Winter Project Week: Continuous 4D shapes

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  Projects List

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  Snapshot of sub-cortical shape evolution. Color denotes magnitude of velocity.

Key Investigators

James Fishbaugh, Hans Johnson, Guido Gerig

Objective

During the 2011 summer project week, we applied our shape regression framework to sub-cortical shapes from a single HD subject. For this project, we plan to begin processing multiple subjects. We would like to compare the trajectories of various measurements of interest, such as volume, across subjects at different stages of disease progression.

Approach, Plan

• Estimate continuous trajectories for sub-cortical structures for multiple subjects
• Investigate volume changes between subjects at different stages of disease progression
• Explore shape evolution for other potentially significant measurements

Progress

HD Subjects

10001

Evolution of volume of sub-cortical structures for subject 10001.

Evolution of left/right structures and total volume for subject 10001.

10002

Evolution of volume of sub-cortical structures for subject 10002.

Evolution of left/right structures and total volume for subject 10002.

10010

Evolution of volume of sub-cortical structures for subject 10010.

Evolution of left/right structures and total volume for subject 10010.

10018

Evolution of volume of sub-cortical structures for subject 10018.

Evolution of left/right structures and total volume for subject 10018.

10022

Evolution of volume of sub-cortical structures for subject 10022.

Evolution of left/right structures and total volume for subject 10022.

10027

Evolution of volume of sub-cortical structures for subject 10027.

Evolution of left/right structures and total volume for subject 10027.

Control Subjects

10003

Evolution of volume of sub-cortical structures for subject 10003.

Evolution of left/right structures and total volume for subject 10003.

10004

Evolution of volume of sub-cortical structures for subject 10004.

Evolution of left/right structures and total volume for subject 10004.

10009

Evolution of volume of sub-cortical structures for subject 10009.

Evolution of left/right structures and total volume for subject 10009.

10014

Evolution of volume of sub-cortical structures for subject 10014.

Evolution of left/right structures and total volume for subject 10014.

10016

Evolution of volume of sub-cortical structures for subject 10016.

Evolution of left/right structures and total volume for subject 10016.

10017

Evolution of volume of sub-cortical structures for subject 10017.

Evolution of left/right structures and total volume for subject 10017.

10059

References

• Fishbaugh, J., Durrleman, S., Gerig, G. A Framework for Longitudinal Data Analysis via Shape Regression . SPIE Medical Imaging 2012: Image Processing. Vol. 8314. (To appear)

• Fishbaugh, J., Durrleman, S., Gerig, G. Estimation of Smooth Growth Trajectories with Controlled Acceleration from Time Series Shape Data. Proc. of Medical Image Computing and Computer Assisted Intervention (MICCAI '11). September 2011.