2013 Project Week:PkModeling for prostate DCE MRI

From NAMIC Wiki
Jump to: navigation, search
Home < 2013 Project Week:PkModeling for prostate DCE MRI

Key Investigators

  • BWH: Andrey Fedorov
  • GE: Jim Miller

Project Description

Objective

  • debug and test the pharmacokinetic modeling extension on prostate DCE MRI data

Approach, Plan

  • previously validated non-open-source implementation of the PK modeling will be used as reference for comparison with the results produced by PkModeling extension
  • prostate DCE MRI data will be used for testing using identically defined AIF
  • success will be achieved if the results produced by PkModeling and the reference software agree

Progress

  • The main source of the inconsistency was due to different models used by the two tools being compared: 2-parameter (Ktrans+ve) vs 3-parameter (Ktrans+ve+fpv). After fixing this, the results were very similar (difference <1% vs 1000%).
  • Bolus arrival time was not estimated in the Slicer PkModeling tool.
  • We may need to re-engineer the module to accommodate multiple models. Further discussions are needed.

References

Retrieved from "https://www.na-mic.org/w/index.php?title=2013_Project_Week:PkModeling_for_prostate_DCE_MRI&oldid=79840"