Projects:NeuralSubstratesOfWorkingMemoryInSchizophrenia

Objective: This project assesses working memory using an auditory verbal version of the n-back task paradigm. Three conditions are presented in blocks in counterbalanced order with increasing working memory load demands (0-, 1-, 2- and 3-back). We will use NAMIC tools to perform novel analyses of the relationships between brain activation and morphological data (e.g., ROI volumes, DTI) in order to improve our understanding of structure-function relationships and connectivity in schizophrenia.

Progress: To date, 16 patients with schizophrenia and 13 healthy controls have been studied. Preliminary analyses on a subgroup have been completed (see image below). Data will be available in year three.

Key Investigators:

• Dartmouth: Andrew Saykin, Robert Roth, Laura Flashman, John West, Thomas McAllister
• BWH: Martha Shenton, Marek Kubicki

Links

• December 20, 2005: Marek Kubicki visit to Dartmouth
• December 14, 2005: Andy Saykin and Group visit to Brigham and Women's Hospital