2011 Winter Project Week:FinslerTractography

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  Projects List

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  Scatter plot of the original FA data through the genu of the corpus callosum of a normal brain.

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  Regression of FA data; solid line represents the mean and dotted lines the standard deviation.

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Key Investigators

• LMI: Antonio Tristán-Vega
• LMI: Carl-Fredrik Westin

Objective

We are coding in ITK the method for fiber bindle segmentation by John Melonako, which is currently written only in MatLab.

Approach, Plan

Our approach for analyzing diffusion tensors is summarized in the IPMI 2007 reference below. The main challenge to this approach is <foo>.

Our plan for the project week is to first try out <bar>,...

Progress

Software for the fiber tracking and statistical analysis along the tracts has been implemented. The statistical methods for diffusion tensors are implemented as ITK code as part of the DTI Software Infrastructure project. The methods have been validated on a repeated scan of a healthy individual. This work has been published as a conference paper (MICCAI 2005) and a journal version (MEDIA 2006). Our recent IPMI 2007 paper includes a nonparametric regression method for analyzing data along a fiber tract.

Delivery Mechanism

This work will be delivered to the NA-MIC Kit as a (please select the appropriate options by noting YES against them below)

1. ITK Module
2. Slicer Module
   1. Built-in
   2. Extension -- commandline
   3. Extension -- loadable
3. Other (Please specify)

References

• Melonakos, J.; Pichon, E.; Angenent, S.; Tannenbaum, A.; "Finsler active contours." IEEE Transactions on Pattern Analysis and Machine Intelligence, 30(3): 412-423, 2008.
• Melonnakos, J.; Mohan, V.; Niethammer, M.; Smith, K.; Kubicki M.; Tannenbaum, A.; "Finsler tractography for white matter connectivity analysis of the cingulum bundle", Procs. MICCAI 2007, LNCS 4791, pp. 36-43.