2010 Summer Project Week Left ventricular scar segmentation

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Fusion of LGE scar data with EP data

Key Investigators

  • Beth Israel Deaconess Medical Center: Dana C. Peters, Felix Liu

Objective

Our goal is to process 3D late gadolinium enhancement (LGE) MR images of the left ventricular myocardium, and to segment scar, and display it in 3D. The scar can be represented as scar transmurality, or using other metrics. We wish to represent the MR scar images in 3D to compare with voltage maps of the myocardium obtained using invasive voltage mapping, by fusing the voltage maps with the scar images. This will lead to interpretation of the relationship between EP findings and scar. This technique can be applied to other areas of study, such as atrial fibrillation.




Approach, Plan

Our approach includes segmentation of the scar, representation, registration with voltage maps, and quantitative evaluation. We will use 3D Slicer, and matlab. A main concern is how to represent/fuse the voltage data, since the voltage data set is a sparse point cloud.

Progress

We are able to display the scar and a representation of the scar in 3D Slicer.


Delivery Mechanism

This work will be delivered to the NA-MIC Kit as a (please select the appropriate options by noting YES against them below)

  1. ITK Module
  2. Slicer Module
    1. Built-in
    2. Extension -- commandline
    3. Extension -- loadable
  3. Other (Please specify)

References

  • Wolf T, Gepstein L, Dror U, Hayam G, Shofti R, Zaretzky A, Uretzky G, Oron U, Ben-Haim SA. Detailed endocardial mapping accurately predicts the transmural extent of myocardial infarction. J Am Coll Cardiol 2001; 37:1590-1597.
  • Desjardins B, Crawford T, Good E, Oral H, Chugh A, Pelosi F, Morady F, Bogun F. Infarct architecture and characteristics on delayed enhanced magnetic resonance imaging and electroanatomic mapping in patients with postinfarction ventricular arrhythmia. Heart Rhythm 2009; 6:644-651.
  • Bogun FM, Desjardins B, Good E, Gupta S, Crawford T, Oral H, Ebinger M, Pelosi F, Chugh A, Jongnarangsin K, Morady F. Delayed-enhanced magnetic resonance imaging in nonischemic cardiomyopathy: utility for identifying the ventricular arrhythmia substrate. J Am Coll Cardiol 2009; 53:1138-1145
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