2010 Summer Project Week White Matter Lesion segmentation

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Home < 2010 Summer Project Week White Matter Lesion segmentation

Key Investigators

  • UNC: Minjeong Kim, Dinggang Shen
  • GE : Xiaodong Tao, Jim Miller


We will continue developing and testing a Slicer module for the white matter lesion segmentation algorithm.

Approach, Plan

We will improve the current version of WMLS Slicer module, especially the generalization performance of the training model and speed. Moreover, we will do more extensive testing by obtaining more data within NA-MIC community.


We have developed and tested a Slicer module for WML segmentation. Moreover, we have improved the speed of segmentation stage after training. We will provide the tutorial for this project meeting to present how to use our learning-based white matter lesion segmenation algorithm in Slicer 3. Subtasks implemented include: (1) a skull stripping algorithm working on T1 weighted images; (2) a fuzzy clustering algorithm for tissue segmentation; (3) a parametric model for gain field correction. All of these subtasks are implemented by using ITK. The training step uses AdaBoost and the segmenation step uses a support vector machine.


  • Zhiqiang Lao, Dinggang Shen, Dengfeng Liu, Abbas F Jawad, Elias R Melhem, Lenore J Launer, Nick R Bryan, Christos Davatzikos, Computer-Assisted Segmentation of White Matter Lesions in 3D MR images, Using Pattern Recognition, Academic Radiology, 15(3):300-313, March 2008.