2010 Winter Project Week Musco Skeletal Segmentation

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Home < 2010 Winter Project Week Musco Skeletal Segmentation

Key Investigators

  • Stanford: Harish Doddi, Saikat Pal, Scott Delp
  • Kitware: Luis Ibanez, Harvey Cline
  • GE Research: Xiaodong Tao


The aim of this project is to develop a methodology for rapid segmentation of knee structures from magnetic resonance (MR) images for subject-specific modeling. The overall goal can be broken down into two specific objectives -
1. Rapid segmentation of target structures into label maps.
2. Generation of simulation-ready models from existing atlas and label maps of individual structures.

Approach, Plan

Objective 1: We have adopted a multi-contrast MR methodology to segment knee bones and cartilage structures. The algorithm utilizes tissue intensity information from multiple MR contrasts to segment structures of interest. Inputs to the algorithm included n registered MR image sets. The algorithm created an n-dimensional space of voxel intensities associated with the n image sets. The user assigned seed points to the structures of interest, and the algorithm created a cluster center for each structure of interest. Cluster radii were calculated based on standard deviations obtained from seed points, and tissue structures were classified as label maps.

For more details, please visit http://www.na-mic.org/Wiki/index.php/Stanford_Simbios_group
a. Incorporate a method to refine label maps (remove undesired bridge connections).
b. Implement an algorithm to assign fiducial points to region boundaries for manual adjustments of geometries.


  • Implemented algorithm to segment structures of interest from multi-constrast MR images.
  • Generated label maps of knee and hip structures.
  • Implemented a pipeline to rapidly refine label maps to isolate regions of interest.
  • Identified an approach to trace geometry boundary and automatically assign fiducial points.