2013 Summer Project Week:Analyzing Breast Tumor Heterogeneity Using 3D Slicer

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Home < 2013 Summer Project Week:Analyzing Breast Tumor Heterogeneity Using 3D Slicer

Key Investigators

  • Boston College: Sneha Dugapal
  • RPI: Vivek Narayan
  • BWH: Jayender Jagadeesan, Tobias Penskofer, Eva Gombos

Objective

We will develop a module in 3D Slicer to segment breast tumors and quantify their heterogeneity. Based off the heterogeneity of the breast tumors, we will categorize them as invasive ductal carcinoma, ductal carcinoma in situ, or fibroadenoma.

Approach, Plan

Our approach is to segment breast tumors using curve-analysis. Our plan for the project week is to develop a module to segment tumors and determine their heterogeneity.

Progress

  • We have developed a module called "OpenCAD" in 3D Slicer to automatically segment breast tumors.
  • The module computes the regions of enhanced perfusion using the curve analysis method and overlays a mask on the DCE-MRI.
  • The threshhold for initial increase and washout of contrast can be adjusted.
  • Label statistics has also been included in the module to compute volume of tumor exhibiting Type I, II and III curves.
  • Heterogeneity metric is also being implemented. We are working on evaluating the clinical relevance of this metric.

Delivery Mechanism

This work will be delivered to the NA-MIC Kit as an extension called OpenCAD.

References