Linear Mixed-effects shape model to explore Huntington's Disease Data

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  Projects List

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  fixed-effects slope for 7 control subjects (10 sub-cortical structures, 3 time points each). blue => expansion, yellow => contraction]

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  fixed-effects slope for 6 HD subjects (10 sub-cortical structures, 3 time points each). blue => expansion, yellow => contraction]

Key Investigators

• UIowa: Hans Johnson, Dave Welch
• Utah: Manasi Datar, Josh Cates, Ross Whitaker

Objective

Make the linear mixed-effects shape model accessible for further exploration of Huntington's Disease Data

Approach, Plan

Meet with UIowa team to:

• give an overview of results from the linear mixed-effects shape model
• explain the ShapeWorks command line tools to optimize and analyze correspondences
• discuss next steps toward making these tools accessible to UIowa team

Progress

preliminary results look promising

ITKv4 module for mixed-effects model available on GitHub

• tested on Windows and Linux
• application to run mixed-effects model on single component shapes (90%)

To Do

• get working code for shape complexes (multiple structures per shape)
• example parameter file for preprocessing shapes, initializing correspondences and applying mixed-effects model
• extracting labels from input labelmap (various components in the shape) - clarify and possibly add a tool to the preprocessing stage

References

M Datar, P Muralidharan, A Kumar, S Gouttard, J Piven, G Gerig, RT Whitaker, PT Fletcher, Mixed-Effects Shape Models for Estimating Longitudinal Changes in Anatomy, STIA 2012