Projects:MixedEffectsShape

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Mixed-Effects Shape Models for Longitudinal Analysis

Visualization of fixed- and random-effects for brain surfaces.

Description

We propose a new method for longitudinal shape analysis that fits a linear mixed-effects model, while simultaneously optimizing correspondences on a set of anatomical shapes. Shape changes are modeled in a hierarchical fashion, with the global population trend as a fixed effect and individual trends as random effects. The statistical significance of the estimated trends are evaluated using specifically designed permutation tests. We also develop a permutation test based on the Hotelling T2 statistic to compare the average shapes trends between two populations. We demonstrate the benefits of our method on a synthetic example of longitudinal tori and data from a developmental neuroimaging study.

Key Investigators

• Utah: Manasi Datar, Prasanna Muralidharan, Sylvain Gouttard, Guido Gerig, Ross Whitaker and P. Thomas Fletcher

Publications

• M Datar, P Muralidharan, A Kumar, S Gouttard, J Piven, G Gerig, RT Whitaker, PT Fletcher, Shape Models for Estimating Longitudinal Changes in Anatomy, STIA 2012