CTSC:ACRIN 09/30/09

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The objectives of the workshop are:

• to enhance interpretation of DICOM images through the use of 3D visualization and analysis
• to gain experience with interactive, quantitative assessment of complex anatomical structures and functional images
• to present current directions of quantitative imaging as a biomarker in clinical trials

Upon completion of this course, participants should be able to

• Describe the methods used for basic analysis of quantitative imaging parameters
• Describe the principles of image registration, segmentation, and volume measurement, and select and use appropriate software for 3D reconstruction
• Identify key analysis and acquisition requirements for multi-center quantitative studies
• Evaluate the impact of quantitative analysis methodology on their research interest

Workshop outline

• 30 min (Dr Kasia Macura, Johns Hopkins): Overview of imaging biomarkers and their use in clinical trials
• 30 min (Dr Randy Gollub, Harvard MGH): Generic principles of image registration, segmentation, visualization (technical aspects)
• 30 min (Dr Jeff Yap, Harvard DFCI): Description and case studies of each of the imaging biomarkers and requirements for standardized acquisition in multi-center trials (e.g. RSNA QIBA)
  • DCE-MRI (pre/post-therapy breast tumor perfusion)
  • volumetric CT (e.g. lung tumor segmentation and volumetric measurement)
  • FDG-PET/CT (pre/post-therapy whole-body imaging with SUV quantification)