CTSC:ACRIN 09/30/09

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The objectives of the workshop are:

  • to enhance interpretation of DICOM images through the use of 3D visualization and analysis
  • to gain experience with interactive, quantitative assessment of complex anatomical structures and functional images
  • to present current directions of quantitative imaging as a biomarker in clinical trials

Upon completion of this course, participants should be able to

  • Describe the methods used for basic analysis of quantitative imaging parameters
  • Describe the principles of image registration, segmentation, and volume measurement, and select and use appropriate software for 3D reconstruction
  • Identify key analysis and acquisition requirements for multi-center quantitative studies
  • Evaluate the impact of quantitative analysis methodology on their research interest

Workshop outline

  • 30 min (Dr Kasia Macura, Johns Hopkins): Overview of imaging biomarkers and their use in clinical trials
  • 30 min (Dr Randy Gollub, Harvard MGH): Generic principles of image registration, segmentation, visualization (technical aspects)
  • 30 min (Dr Jeff Yap, Harvard DFCI): Description and case studies of each of the imaging biomarkers and requirements for standardized acquisition in multi-center trials (e.g. RSNA QIBA)
    • DCE-MRI (pre/post-therapy breast tumor perfusion)
    • volumetric CT (e.g. lung tumor segmentation and volumetric measurement)
    • FDG-PET/CT (pre/post-therapy whole-body imaging with SUV quantification)


Presentations are posted on the CTSA IWG website and wiki.


CTSA wiki