NA-MIC Internal Collaborations:New
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Diffusion Image Analysis
Fiber Tract Extraction and Analysis
- Corpus Callosum Fiber Tractography in Schizophrenia (Dartmouth, BWH, MIT)
- Tensor estimation and Monte-Carlo simulation (UNC, Utah)
- ITK Stochastic Tractography Filter (MIT, BWH)
- Volumetric White Matter Connectivity (Utah)
- DTI Atlas-Building (UNC, BWH)
- Inferior Frontotemporal Connections in Schizophrenia (BWH, MIT)
- Automatic Clustering of Corpus Callosum and FA Analysis (BWH, MIT)
- FA Analysis of Fornix Tractography in Schizophrenia (BWH, MIT)
- A Diffusion Tensor Imaging and Genetics Study of Psychosis Across the Lifespan - Project in Recruitment Phase (Toronto, BWH)
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Geodesic Tractography SegmentationIn this work, we provide an energy minimization framework which allows one to find fiber tracts and volumetric fiber bundles in brain diffusion-weighted MRI (DW-MRI). More... New: J. Melonakos, E. Pichon, S. Angenet, and A. Tannenbaum. Finsler Active Contours. IEEE Transactions on Pattern Analysis and Machine Intelligence, 2007 (in press). |
Fractional Anisotropy Analysis
- Corpus Callosum Regional FA analysis in Schizophrenia (BWH, UNC, Dartmouth)
- Fractional Anisotropy of the Corpus Callosum and Anterior Commissure (BWH, MIT, Dartmouth)
- Fractional Anisotrophy in the Uncinate Fasciculus in Schizophrenia and Bipolar I Disorder--replication and extension of Kubicki study (Dartmouth, BWH)
- Corpus Callosum Probabilistic Subdivision and FA Analysis (BWH, UNC)
Path of Interest Analysis
- Integrity of Fronto-Temporal Circuitry in Schizophrenia using Path of Interest Analysis (Dartmouth, MGH, Isomics, BWH)
- ITK implementation of POIStats, and Integration into Slicer3 (MGH, Isomics),
- Dartmouth Data Image Format Compatibility in Application of POIStats (MGH, Isomics, Kitware, Dartmouth)
- Anatomical Connectivity of Regions of Functional Activation (BWH)
Validation
- DTI Validation (UCI, MGH, UNC, MIT)
Algorithm/Software Infrastructure
- DTI Software/Algorithm Infrastructure (Utah, UNC)
- Tensor based statistics (BWH, Utah)
- Diffusion tensor image filtering (Utah, BWH)
- Non-rigid EPI Registration (MGH, Kitware, Dartmouth)
- Fiber Tools Integration with Slicer 3 (UNC, GE, Isomics)
- Rician Noise Remvoal in Diffusion Tensor MRI (Utah)
- Finsler Tractography in ITK (Georgia Tech, Kitware): 4-block PPT Jan 2007
- Finsler Levelsets in ITK (Georgia Tech, Kitware): 4-block PPT Jan 2007
- Restoration of DWI data using a Rician LMMSE Estimator (BWH)
Structural Image Analysis
Image Segmentation
Knowledge-Based Bayesian Segmentation
This ITK filter is a segmentation algorithm that utilizes Bayes's Rule along with an affine-invariant anisotropic smoothing filter. More...
New: J. Melonakos, Y. Gao, and A. Tannenbaum. Tissue Tracking: Applications for Brain MRI Classification. SPIE Medical Imaging, 2007.
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- Brain Tissue Classification and Subparcellation of Brain Structures (BWH, MIT, Kitware)
Rule-Based Striatum Segmentation
In this work, we provide software to semi-automate the implementation of segmentation procedures based on expert neuroanatomist rules for the striatum. More...
New: Al-Hakim, et al. Parcellation of the Striatum. SPIE MI 2007.
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Rule-Based DLPFC Segmentation
In this work, we provide software to semi-automate the implementation of segmentation procedures based on expert neuroanatomist rules for the dorsolateral prefrontal cortex. More...
New: Al-Hakim, et al. A Dorsolateral Prefrontal Cortex Semi-Automatic Segmenter. SPIE MI 2006.
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Multiscale Shape Segmentation Techniques
To represent multiscale variations in a shape population in order to drive the segmentation of deep brain structures, such as the caudate nucleus or the hippocampus. More...
New: Delphine Nain won the best student paper at MICCAI 2006 in the category "Segmentation and Registration" for her paper entitled "Shape-driven surface segmentation using spherical wavelets" by D. Nain, S. Haker, A. Bobick, A. Tannenbaum.
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Stochastic Methods for Segmentation
New stochastic methods for implementing curvature driven flows for various medical tasks such as segmentation. More...
New: Currently under investigation.
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Statistical/PDE Methods using Fast Marching for Segmentation
This Fast Marching based flow was added to Slicer 2. More...
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Atlas Renormalization for Improved Brain MR Image Segmentation across Scanner Platforms
Atlas-based approaches have demonstrated the ability to automatically identify detailed brain structures from 3-D magnetic resonance (MR) brain images. Unfortunately, the accuracy of this type of method often degrades when processing data acquired on a different scanner platform or pulse sequence than the data used for the atlas training. In this paper, we improve the performance of an atlas-based whole brain segmentation method by introducing an intensity renormalization procedure that automatically adjusts the prior atlas intensity model to new input data. Validation using manually labeled test datasets has shown that the new procedure improves the segmentation accuracy (as measured by the Dice coefficient) by 10% or more for several structures including hippocampus, amygdala, caudate, and pallidum. The results verify that this new procedure reduces the sensitivity of the whole brain segmentation method to changes in scanner platforms and improves its accuracy and robustness, which can thus facilitate multicenter or multisite neuroanatomical imaging studies. More...
New: IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 26, NO. 4, APRIL 2007
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- EMSegmenter Software Development (BWH, MIT, Kitware) 4-block PPT Jan 2007
Image Registration
Optimal Mass Transport Registration
The goal of this project is to implement a computationaly efficient Elastic/Non-rigid Registration algorithm based on the Monge-Kantorovich theory of optimal mass transport for 3D Medical Imagery. Our technique is based on Multigrid and Multiresolution techniques. This method is particularly useful because it is parameter free and utilizes all of the grayscale data in the image pairs in a symmetric fashion and no landmarks need to be specified for correspondence. More...
New: Tauseef ur Rehman, A. Tannenbaum. Multigrid Optimal Mass Transport for Image Registration and Morphing. SPIE Conference on Computational Imaging V, Jan 2007.
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- Parallelization of ITK for deformable registration (Kitware, GE, Utah), 4-block PPT Jan 2007
- Group-wise Registration of Medical Images (MIT, BWH, MGH), 4-block PPT Jan 2007
Morphometric Measures and Shape Analysis
- Shape Analysis for the caudate and corpus callosum data (BWH, UNC, Georgia Tech, Dartmouth)
- Shape Analysis of the hippocampus (Dartmouth, UNC, BWH)
Multiscale Shape Analysis
We present a novel method of statistical surface-based morphometry based on the use of non-parametric permutation tests and a spherical wavelet (SWC) shape representation. More...
New: D. Nain, M. Styner, M. Niethammer, J. J. Levitt, M E Shenton, G Gerig, A. Bobick, A. Tannenbaum. Statistical Shape Analysis of Brain Structures using Spherical Wavelets. Accepted in The Fourth IEEE International Symposium on Biomedical Imaging (ISBI ’07) that will be held April 12-15, 2007 in Metro Washington DC, USA.
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- UNC Shape Analysis with LONI pipeline for clinical investigators (UNC, UCLA)
- Population Studies (UNC, GE)
- Multi-site morphometry in Mild Cognitive Impairment (UCI, mBIRN?)
- Multi-site morphometry in Schizophrenia (UCI, FBIRN)
- Automated shape model construction (Utah, BWH)
- Neural substrates of apathy in schizophrenia (Dartmouth, Isomics)
Spherical Wavelets
Cortical Surface Shape Analysis Based on Spherical Wavelets. We introduce the use of over-complete spherical wavelets for shape analysis of 2D closed surfaces. Bi-orthogonal spherical wavelets have been proved to be powerful tools in the segmentation and shape analysis of 2D closed surfaces, but unfortunately they suffer from aliasing problems and are therefore not invariant to rotation of the underlying surface parameterization. In this paper, we demonstrate the theoretical advantage of over-complete wavelets over bi-orthogonal wavelets and illustrate their utility on both synthetic and real data. In particular, we show that the over-complete spherical wavelet transform enjoys significant advantages for the analysis of cortical folding development in a newborn dataset. More...
New: IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 26, NO. 4, APRIL 2007
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Topology Correction
Geometrically-Accurate Topology-Correction of Cortical Surfaces using Non-Separating Loops. We propose a technique to accurately correct the spherical topology of cortical surfaces. Specifically,we construct a mapping from the original surface onto the sphere to detect topological defects as minimal nonhomeomorphic regions. The topology of each defect is then corrected by opening and sealing the surface along a set of nonseparating loops that are selected in a Bayesian framework. The proposed method is a wholly self-contained topology correction algorithm, which determines geometrically accurate, topologically correct solutions based on the magnetic resonance imaging (MRI) intensity profile and the expected local curvature. Applied to real data, our method provides topological corrections similar to those made by a trained operator. More...
New: IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 26, NO. 4, APRIL 2007
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- ITK Spherical Wavelet Transform Filter (Georgia Tech,GE, Kitware): 4-block PPT Summer 2006, 4-block PPT Jan 2007
- UNC shape analysis with Spherical Wavelet Features (GaTech, UNC): 4-block PPT Jan 2007
- Integrating KWMeshVisu into Slicer (UNC, Kitware), 4-block PPT Jan 2006, 4-block PPT Jan 2007
- Integrating UNC Shape Analysis into Slicer (UNC, Kitware)
- Correspondence of complex structures using (Curvature + Location) MDL (UNC)
QDEC: An easy to use GUI for group morphometry studies
Qdec is a application included in the Freesurfer software package intended to aid researchers in performing inter-subject / group averaging and inference on the morphometry data (cortical surface and volume) produced by the Freesurfer processing stream. The functionality in Qdec is also available as a processing module within Slicer3, and XNAT. More...
See: Qdec user page
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- Adaptive, Particle-Based Sampling for Shapes and Complexes (Utah, UNC)
- Thickness Slicer3 Module (BWH, Isomics)
- Genus Zero Slicer3 Module (BWH, Isomics)
- Morphometry of Frontal circuitry in patients with schizophrenia with and without co-occurring substance use disorder (Dartmouth, Isomics)
fMRI Analysis
Functional Activation Analysis
- Neural Substrates of Working Memory in Schizophrenia: A Parametric 3-Back Study (Dartmouth, Harvard)
- Brain Activation during a Continuous Verbal Encoding and Recognition Task in Schizophrenia (Dartmouth, Harvard)
- Fronto-Temporal Connectivity in Schizophrenia during Semantic Memory (Dartmouth, Harvard)
- Imaging Phenotypes in Schizophrenics and Controls (UCI, Toronto)
- Attentional Circuits in Schizophrenia as revealed by fMRI and PET (UCI)
- Serotonergic / dopaminergic genes and processing of threatening stimuli in panic disorder: an imaging genetics study (Toronto)
Algorithm and Software Infrastructure
- fMRI Statistics Software Infrastructure (GE, Isomics, Kitware, MIT)
- Spatial Regularization for fMRI Detection (MIT, Harvard)
Conformal Flattening
The goal of this project is for better visualizing and computation of neural activity from fMRI brain imagery. Also, with this technique, shapes can be mapped to shperes for shape analysis, registration or other purposes. Our technique is based on conformal mappings which map genus-zero surface: in fmri case cortical or other surfaces, onto a sphere in an angle preserving manner. More...
New: Y. Gao, J. Melonakos, and A. Tannenbaum. Conformal Flattening ITK Filter. ISC/NA-MIC Workshop on Open Science at MICCAI 2006.
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NA-MIC Kit
NAMIC Software Process
- CMake - NAMIC Kit Building (Kitware)
- CPack - NAMIC Kit Distribution (Kitware)
- Dart 2 and CTest - Software Quality (GE, Kitware)
Software Infrastructure
- Slicer 3 (Isomics, GE, Kitware, UCSD, UCLA)
- MRML (Isomics, Kitware, GE)
- Coordinate Systems (GE, Isomics)
- IO Unification (GE, Isomics)
- Execution Model (GE)
- Grid Computing (UCSD, GE, Kitware, Isomics)
- Licenses Unification (Kitware, Isomics)
- Toolkits
Training & Dissemination
- Training Material and Workshops for NA-MIC Kit (MGH, BWH)
- Dissemination for NA-MIC (Isomics, Kitware, Harvard)
Other Projects
Numerical Recipies Replacement
Our objective is to replace algorithms using the proprietary Numerical Recipes for C source base in FreeSurfer in the efforts to open-source FreeSurfer. This project has been completed through the use of the open source packages VXL (VNL) and Cephes. This includes the complete replacement of all Numerical Recipes in C code, and the implementation of a battery of unit tests for each replaced function. Currently the open source release is at a beta stage, and 25 beta releases of the source have been made. We anticipate a complete open source release in first quarter 2008. More...
New: Completed
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